GLP-2 (Glucagon-Like Peptide-2) is a naturally occurring peptide hormone derived from the proglucagon gene and primarily produced in the intestinal L-cells. It has been studied for its role in supporting gastrointestinal structure and function, particularly in relation to intestinal growth, nutrient absorption, and mucosal integrity.

Preclinical and clinical research suggests that GLP-2 may influence epithelial cell proliferation, enhance intestinal barrier function, and modulate blood flow within the gastrointestinal tract. These mechanisms are believed to underlie its observed effects in studies examining intestinal adaptation, nutrient transport, and mucosal repair signaling. GLP-2 interacts with specific receptors located in the gut, contributing to regulatory pathways involved in digestive physiology.

Beyond structural support of the gastrointestinal lining, GLP-2 has also been investigated for its potential influence on inflammatory balance within intestinal tissues and overall digestive resilience. Ongoing research continues to evaluate its impact on gut-associated signaling pathways, epithelial regeneration, and gastrointestinal homeostasis.